Food Allergy Management and Prevention
Support Tool for Infants and Toddlers
REAct

Recognize anaphylaxis

Prevention and Emergency Preparedness Handout
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ACT to Prevent Allergic Reactions


Severe Symptoms

If a young child is having an allergic reaction to a food, any of the severe symptom below suggest likely anaphylaxis and that caregivers should treat with epinephrine (1,2):

Severe symptoms that suggest trouble with breathing or swelling involving the airway:

Severe symptoms that suggest cardiovascular involvement:

Severe Skin symptoms (quickly progressing or all over):

Severe Gastrointestinal Symptoms:

Severe Neurologic Symptoms:

Other Symptoms

Other symptoms can also be seen in infants and toddlers, and if they are from more than one system or progress then these can signify anaphylaxis as well and require epinephrine(1,2,):

Skin symptoms:

Mucosal or upper airway symptoms:

Gastrointestinal Symptoms:

Neurological Symptoms:

Treat all anaphylaxis with epinephrine.

Give epinephrine

Activate emergency response

Videos for Parents for Infant Anaphylaxis

Ask the Allergist: Infant Anaphylaxis and Food Allergies
Anaphylaxis for the Infant: Special Considerations for this Growing Population

References

  1. Pistiner M, Mendez-Reyes JE, Eftekhari S, Carver M, Lieberman J, Wang J, Camargo CA Jr. Caregiver reported presentation of severe food-induced allergic reactions in infants and toddlers. JACI In-practice. 2020. Nov 18;S2213-2198(20)31224-1. doi: 10.1016/j.jaip.2020.11.005.
  2. Julie Wang, Scott H. Sicherer, AAP SOAI. Guidance on Completing a Written Allergy and Anaphylaxis Emergency Plan. Pediatrics. Mar 2017, 139 (3) e20164005; doi: 10.1542/peds.2016-4005.
  3. Dribin TE, et al. Severity grading system for acute allergic reactions: a multidisciplinary Delphi study. Journal of Allergy and Clinical Immunology. 2021 Jan 19. doi: 10.1016/j.jaci.2021.01.003.
Basic Prevention

Avoid Allergen

Communicate

Teach

Prevention and Emergency Preparedness Handout
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ACT for Prevent Allergic Reactions
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AAAAI Ages and Stages
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Author Manuscript – Ages and Stages of Food Allergy

IgE Mediated

These sections contain the same information as in the PDF handouts throughout this section, but are formatted for easier placement within EMR systems to place in after visit patient handouts.

Label Reading for Food Allergens

Read Every Label, Every Time

The 9 Major Allergens Are:

Milk or Dairy
Eggs
Peanuts
Tree nuts (almonds, hazelnuts, walnuts, pecans etc.)
Soy
Wheat
Fish (cod, bass, salmon, tuna etc.)
Crustacean shellfish (lobster, shrimp, crab, etc.)
Sesame

Note:  While the 8 major allergens are responsible for the majority of allergic reactions, ALL allergens must be taken seriously.

The Food and Drug Administration (FDA) enforces the Food Allergen Labeling and Consumer Protection Act (FALCPA) labeling law. FALCPA applies to all domestic and imported packaged foods and the 8 major allergens, which must be written in clear, plain language and labeled when in flavorings, colorings or other additives.

Note: FALCPA only applies to the 8 major allergens!

The allergens below are not included in the major 8 allergens and therefore are not included in the labeling law:

The following items are not regulated by the FDA or the labeling law:

Major 8 Allergens Can be Listed in 1 of 2 Way

1 WITHIN THE BODY OF THE INGREDIENTS
Be aware that allergens may be written in plain language in the body of a products ingredient list.

OR

2 FOLLOWING A CONTAINS STATEMENT

A “Contains” statement:

Remember “contains” statements only apply to the 8 MAJOR allergens and companies can choose to not use them.

Advisory or Precautionary Statements

Note: For children with celiac disease or gluten sensitivities, it may be best to look for “gluten-free products” because labeling can be inconsistent. Wheat is one of the major eight allergens, but other sources of gluten such as barley, rye and oat are not.

Cross Contact

What is Cross Contact?

Cross contact is the unplanned presence of food allergens. It occurs when an allergen protein is unintentionally transferred to an allergen free food or object. Cross contact can be invisible to the eye and can come from many places. Even small amounts of an allergen can cause an allergic reaction.

This means that your child can accidently be exposed to an allergen through:

Objects (Utensils, cooking surfaces, highchairs, pacifiers, sponges, bib, apron, etc.)

Food (Steam, splatter, accidental contamination, frying oil)

Saliva (People, pets, binky, Sophie the Giraffe, musical instrument, etc.)

Who needs to know about allergen cross contact?

Any caregiver for your child. Babysitters, siblings, grandparents, extended family, friends, teachers, etc. Routine teaching of all caregivers about sources of cross contact and prevention of exposure is essential.

Children explore their environments with their hands and often put them, or other objects in their mouths.

Younger children are more likely to put their hands in their mouths and noses; therefore, caregivers should have increased awareness and wash their children’s hands often Avoid sharing of food, utensils, water bottles and anything else that may go in their mouth, such as musical instruments.

Cross Contamination vs Cross Contact

Cross contamination occurs when microorganisms such as bacteria contaminate food and result in a food borne illness. Unlike cross contact, the risks of cross contamination may be eliminated with proper cooking techniques, whereas proper cooking does not reduce or eliminate the chances of a food allergy reaction.

Tips for Preventing Cross Contact When Serving and Preparing Food

Preparing

Cooking

Cleaning

Keep it simple, limit multiple ingredient dishes, cook from scratch.

Videos for Parents for Anaphylaxis for the Infant

Deciding What Foods to Introduce

This article is being displayed from Early Food. Any changes to Early Food’s article will be reflected here as well.

Placing a Referral for an Allergist

Pediatric Allergist

A pediatric allergist is a medical doctor who specializes in managing allergic issues for children. Allergists perform the following procedures to screen patients for allergies and can help patients interpret the results to proceed with allergy management:

When experiencing any of the following allergic issues, an allergist can also assist patients in determining the best course of treatment:

Pediatric allergists also help managing non-IgE mediated allergies and various atopic conditions, including the following:

Specialty Consult Request form
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AAP Specialty Consult Request form

Older populations can participate in studies that utilize immunotherapies (including oral immunotherapy, subcutaneous immunotherapy, or sublingual immunotherapy), which may help research subjects decrease the likelihood of reacting to foods that they are allergic to.

For infants and toddlers specifically, pediatric allergists assist families to determine when and in what form to introduce commonly allergenic foods into the diet, and what strategies and steps to take in the lifestyle and in the home to prevent the development of food allergies. Allergists work closely with families to determine the best course of action for their child’s health needs and help guide families on how to integrate foods back into an infant or toddler’s diet over time and/or in a controlled setting. They are able to update families on the most up to date science when it comes to food allergies in this population.

The American Academy of Pediatrics Specialty Consult Request is a referral form that general pediatricians can use to refer their patients to see a pediatric specialist. If you would like to refer your patient to see a pediatric allergist, pediatric dermatologist, pediatric gastroenterologist, or any other pediatric specialist, please complete this form and send it to the applicable specialist.

On these sheets, there are sections where you as the primary care provider can specify what clinical problems your patient may be experiencing where you would like a pediatric specialist to also assess. If you have specific questions related to your patient’s care that you would like addressed with the specialist, those can also be specified on this form. Directives to the specialists for care can also be provided on this sheet, including any prior interventions and relevant patient history.

If you would like to refer your patient to a pediatric allergist, American Academy of Allergy, Asthma and Immunology (AAAAI) and American College of Allergy, Asthma, and Immunology (ACAAI) both have information on how to find a local allergist in your community.

Make an Anaphylaxis Action Plan

This page will guide you to:

  1. Formalize an Anaphylaxis Action Plan, ensuring caregivers know what to do if anaphylaxis presents.
  2. Counsel families on the unique ways infants and toddlers demonstrate anaphylaxis. 
  3. Teach the REAct framework – Recognize, Epinephrine, and Activate – providing a simple, memorable model for families to react to anaphylaxis.

1. Formalizing the Anaphylaxis Action Plan

People responsible for a child with food allergies need to know which symptoms suggest a severe allergic reaction and when to administer (give) an epinephrine auto-injector.

Anaphylaxis Action Plans are created by a healthcare provider and should be made for families of patients with IgE-mediated food allergy.

This provides families and caregivers with information on common signs and symptoms of an allergic reaction and when to give epinephrine.

We suggest using the American Academy of Pediatrics (AAP) anaphylaxis action plan, though other action plans from different organizations do exist.

For current information from the AAP on how to fill out an action plan, see Guidance on Completing a Written Allergy and Anaphylaxis Emergency Plan.

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Anaphylaxis Action Plan

2. Counseling Families on Infant & Toddler Symptoms

Anaphylaxis in infants and toddlers can look different than in older children and adults. Additionally, infants are unable to verbalize their symptoms. Families should be aware of the things to look out for with their child, especially since symptoms can start mild but progress quickly. Consider using the below infographic to discuss some of the ways infants and toddler allergic reactions may present differently from older children.

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Recognizing Anaphylaxis in Infants and Toddlers

3. Teaching the REAct Framework

You can use the REAct framework for counseling families when faced with an allergic emergency: 

Key Family Talking Points:

References

  1. Wang, J., & Sicherer, S. H. (2017). Guidance on completing a written allergy and anaphylaxis emergency plan. Pediatrics, 139(3).
  2. Dosanjh, A. (2013). Infant anaphylaxis: The importance of early recognition. Journal of Asthma and Allergy, 6, 103-107.
  3. Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Camargo, C. A., Simons, F. E. R., & Lieberman, P. L. (2019). Guiding principles for the recognition, diagnosis, and management of infants with anaphylaxis: An expert panel consensus. Journal of Allergy and Clinical Immunology, 7(4), 1148-1156.
Epinephrine Information and Training

Epinephrine is the first-line treatment for anaphylaxis, with delays in administration associated with increased mortality.(1) Epinephrine autoinjectors provide an effective way for individuals without clinical training to administer epinephrine to themselves or another person.

During visits with patients who have been prescribed EAIs, as recommended by the Anaphylaxis Practice Parameter, we also recommend that clinicians routinely review the essentials of EAI carriage, storage, and use; encourage patients to regularly practice EAI administration with a trainer device; and discuss strategies to manage barriers to adherence that patients may have experienced.

Dosing

Recommended dosing is 0.01mg/kg up to 0.5mg IM 1:1000 epinephrine (1mg/ml)

In the US, there are 3 different dosage autoinjectors available:

  1. 0.1 mg (only available in Auvi-Q): approved for patients under 15 kg
    Recommend upsizing to 0.15 mg at 13 kg
  2. We suggest clinicians prescribe either the 0.1 mg or the 0.15 mg EAI dose for infants/toddlers weighing less than 15 kg, as recommended by the 2023 Anaphylaxis Practice Parameters
  3. 0.3 mg: approved for patients 30 kg and over

Epinephrine Autoinjectors

If a child has a suspected IgE-mediated food allergy, it is important to prescribe an epinephrine autoinjector. There are currently 4 different epinephrine autoinjector models available in the United States. All autoinjectors come in two-packs, and patients should keep both devices with them at all times. While each autoinjector has similar general administration steps, there are slight differences for each one that should be discussed when training families. A comparison of each autoinjector and resources for training families on administration can be found in the table at the bottom of this page.

Training


Important Take-Home Points to Discuss with Families:

Device Doses Trainer included? Other Notes
EpiPen and Authorized Generic by Mylan0.15 mg
0.3 mg
Yes EpiPen and Mylan Savings Cards
Auvi-Q0.1 mg
0.15
mg 0.3 mg
Yes0.1 mg dosing is recommended for children under 15 kg (33 lbs) Device includes voice instruction
Teva Epinephrine Auto-Injector 0.15 mg
0.3 mg
Yes Teva Savings Card
Impax Epinephrine Auto-Injector (Generic of Adrenaclick) 0.15 mg
0.3 mg
No
Order Trainer Online
Impax Savings Card

Video: Anaphylaxis for the Infant

Anaphylaxis for the Infant: Special Considerations for this Growing Population

References

  1. Simons FE. First-aid treatment of anaphylaxis to food: focus on epinephrine. Journal of Allergy and Clinical Immunology. 2004 May 1;113(5):837-44.
  2. Simons FE, Clark S, Camargo Jr CA. Anaphylaxis in the community: learning from the survivors. Journal of Allergy and Clinical Immunology. 2009 Aug 1;124(2):301-6.
How to Read a Label


Label Reading for Food Allergens

The most important take-home points when discussing how to read a label are:

reading food label

Food Allergy Labeling Law

The Food and Drug Administration (FDA) enforces the Food Allergen Labeling and Consumer Protection Act (FALCPA) labeling law. FALCPA applies to all domestic and imported packaged foods and the 9 major allergens, which must be written in clear, plain language and labeled when in flavorings, colorings or other additives.   

FALCPA only applies to the 9 major allergens:

Milk or Dairy
Egg
Peanuts
Tree nuts (almonds, hazelnuts, walnuts, pecans etc.)
Soy
Wheat
Fish (cod, bass, salmon, tuna etc.)
Crustacean shellfish (lobster, shrimp, crab, etc.)
Sesame

Note: While the 9 major allergens are responsible for the majority of allergic reactions, ALL allergens must be taken seriously.

The following items are not regulated by the FDA or FALCPA:

The following items are not regulated by the FDA or the labeling law:


Major 9 allergens can be listed in two different ways

1 Within the body of the ingredients: Allergens can be written in plain language in the body of a products ingredient list.

or

2 Following a “contains” statement: These statements only apply to the 9 major allergens, and companies can choose to not use them.

What About Advisory or Precautionary Statements?

Note: For children with celiac disease or gluten sensitivities, it may be best to look for “gluten-free products” because labeling can be inconsistent. While wheat is one of the major eight allergens, other sources of gluten such as barley, rye and oat are not.

Download AAAAI Ages and Stages
Label Reading for Food Allergens

Download in
English or Spanish

Avoiding Cross Contact

Cross contact is the presence of unintended food allergen

Common sources of cross contact:

The following are just a few examples of common sources of cross contact. See the table at the end of this page for more examples of cross contact and potential alternatives.

Objects Utensils, cooking surfaces, highchairs, pacifiers, sponges, bib, apron, etc.
Using the same tongs to flip shrimp and a chicken breast. Without properly washing the tongs in-between use, allergens may be transferred to the chicken breast.

Food Steam, splatter, accidental contamination, frying oil
Removing nuts from a salad or scraping cheese off a cheeseburger.

Saliva People, pets, binky, Sophie the Giraffe, musical instrument, etc.
Sucking on another baby’s pacifier after they had a bottle of milk-based formula.

Who needs to know about allergen cross contact?

Any caregiver, including babysitters, siblings, grandparents, extended family, friends, and teachers. Routine teaching of all caregivers about sources of cross contact and prevention of exposure is essential.

Things to Consider with Infants/Toddlers:

Children explore their environments with their hands and often put them, or other objects in their mouths. Younger children are more likely to put their hands in their mouths and noses, therefore caregivers should have increased awareness and wash their children’s hands often. Avoid sharing of food, utensils, water bottles and anything else that may go in their mouth, such as musical instruments.

Cross Contamination vs Cross Contact

Cross contamination occurs when microorganisms such as bacteria contaminate food and result in a food borne illness. Unlike cross contact, the risks of cross contamination may be eliminated with proper cooking techniques, whereas proper cooking does not reduce or eliminate the chances of a food allergy reaction.

Tips for Preventing Cross Contact When Serving and Preparing Food

Cross Contamination

Download in
English or Spanish

Preparing

Cooking

Cleaning


Objects

SourceExamplesWays to Avoid
Kitchen Utensils, Serving SpoonsUsing a knife to spread peanut butter, not cleaning it properly, and then using it to spread jam.

Serving mac and cheese, and then using the same spoon to serve green beans.
Wash utensils and serving spoons in the dishwasher or with soap and water in between each use.

Use separate sets of serving spoons during meals for allergen vs non-allergen food items.
Cooking Surfaces, Cutting Boards, Counter TopsCooking fish or shellfish on the same grill as steak.

Scrambling eggs and then cooking a grilled cheese on same griddle.

Cutting cheese and then fresh fruit on the same cutting board.
Clean grill surface with soap and water in between uses.

Prepare the allergic child’s food first.

Consider having separate cooking surfaces and cutting boards as allergen-safe.

Clean counters with soap and water or commercial wipes before and after cooking.
Deep Fryers, Cooking Oils, and Seasoned WokFrench fries that have been fried in the same oil as shrimp.

Cooking allergen safe foods in a seasoned wok.
Avoid food cooked in a common deep fryer.

Consider simple dished cooked on surfaces that are easily cleaned.
Pots, Pans, Cooling Racks, Small AppliancesMaking wheat bread in a bread pan, and then making gluten free bread.

Blending a smoothie with cow’s milk, and then one with plant-based milk.
Clean properly in-between uses or designate specific pans and small appliances as allergen-free.

Consider cooking the allergy-safe foods first.

Saliva

SourceExamplesWays to Avoid
SalivaKissing your child or cleaning their binky with your mouth after you eat a granola bar with allergens.

Sharing toys, teething rings, pacifiers with other infants.

Sharing utensils, cups, plates, water bottles, food, or drinks.

Pets eat treats with milk and then lick child’s face, or babies eating dog food.
Do not share food, drinks, cups, plates or eating utensils.

Wash properly or wipe down toys, pacifiers, teething rings regularly.

Keep pet food and treats out of reach of children.

Food

SourceExamplesWays to Avoid
AirborneSteam from cooking allergens, such as shellfish in a pot on the stove.

Allergic child inhaling wheat, peanut, etc. flour while preparing baked goods.
Consider not cooking allergens that could travel through steam while the allergic child is home, or avoid these allergens in your home.

Do not prepare or cook allergens in your home.
HandsFailing to wash your hands after handling nuts, and then preparing your child’s meal, or setting them up in their highchair.

Siblings playing with a toy after eating allergen, and then handing it to allergic child.
Wash hands with warm water and soap before and after preparing each meal and setting up highchair.

Regularly wipe down toys to decrease risk of exposure from child to child.
Sponges, Dish Towels, Oven Mitts, ApronsUsed a sponge to clean a mac and cheese baking pan, and then the child’s sippy cup.

Wiping hands on apron instead of washing them in between each task.
Considering using disposable wipes, or paper towels, or designating specific cleaning instruments for allergen free cookware, and dinnerware.

Wash hands properly in-between tasks.

Avoiding Cross-Contact While Dining Out

Clear Communication:

Avoid High-Risk Foods:

No Sharing:

When dining out with a child who has food allergies, clear communication is key. Talk to the manager and/or chef, in addition to your server, to ensure that they understand your child’s needs. It’s best to avoid restaurants where there is a language barrier, and clear communication is difficult. If possible, call ahead and discuss your child’s allergy with a manager.

To minimize the risk of cross-contact, avoid ordering combination dishes like stews, soups, and sauces, as they often contain hidden ingredients and may have been prepared before your arrival. Fried foods, salad bars, and buffets are also common sources of cross-contact. Note that certain types of restaurants may be riskier for those with specific allergies (like an ice cream parlor for a child with dairy, peanut, or tree nut allergies), so research beforehand can help mitigate risks.

Finally, never share food that was not prepared specifically for your child with food allergies. The precautions taken in the preparation of your dish may not have been taken for others.

For Allergy

Food Reaction Evaluation (Food Reaction History):

This text can be used for patients who have either suspected or confirmed food allergies, based on testing or prior reactions. You can copy and paste it into your EMR system to use during well-child visits or follow up appointments.

There is concern that patient had food reaction to [LIST FOODS].

The patient has known food allergies to [LIST FOODS].

Food Reaction Evaluation (Food Reaction Assessment and Plan):

This text can be used to document that the family was provided guidance on their child’s suspected food allergy and that a referral will be placed for pediatric allergy. This section also includes information on what educational resources to provide the family and what dosage of epinephrine auto-injector to prescribe. You can copy and paste it into your EMR system to use during well-child visits or follow up appointments.

Based on the patient’s reaction, there is a concern for an IgE mediated food allergy.  The patient should be referred to an allergist for further evaluation. The family was counseled to avoid [INSERT FOOD] as well as foods they have known allergies to including [LIST KNOWN FOOD ALLERGIES OR REMOVE IF N/A]. The family was counseled on label reading, cross contact avoidance and provided with relevant educational material in addition to an anaphylaxis action plan [NOTE TO DOCTOR TO PROVIDE LABEL READING, CROSS CONTACT PATIENT EDUCATION, AND ANAPHYLAXIS PLAN]. The family was counseled to continue to eat allergenic foods they are tolerating regularly so they do not lose their tolerance.

An epinephrine autoinjector two-pack [CHOOSE DOSE: 0.1 MG FOR WT LESS THAN 13KG OR 0.15 MG IF 0.1 MG NOT AVAILABLE; 0.15 MG FOR WT 13 to 25 KG; 0.3 MG FOR WT GREATER THAN 25 KG] was prescribed and should be available at all times.  Epinephrine auto-injector training  was provided and indications for use of epinephrine reviewed.