Current Research and Information on Foods Other Than Peanut
The USDA HHS Dietary Guidelines for Americans 2020-2025 encourages the introduction of complementary foods at about 6 months and recommends that potentially allergenic foods be introduced along with other complementary foods. In addition to peanuts, the Dietary Guidelines for Americans 2025 recommend eggs, cow milk products, tree nuts, wheat, crustacean shellfish, and soy be introduced when other complementary foods are introduced. Some infants may show developmental signs of readiness before age 6 months, but introducing complementary foods before age 4 months – or waiting until after 6 months – is not recommended (1).
This section provides a summary of the current research for other common allergens as well as links to the papers cited.
Reference
- U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2020-2025. 9th Edition. December 2020. Available at DietaryGuidelines.gov.
Eggs
There is moderate evidence that egg introduction at around 6 months is associated with a lower prevalence of egg allergy versus later introduction.
Egg allergy currently impacts approximately 2% of the US population under 5 years of age. Current guidelines emphasize the importance of early introduction of highly allergenic foods, including egg, as a means of food allergy prevention. This shift in guidance has led to a younger patient population presenting with egg allergy concerns, and currently, there is limited research on egg restriction’s impact on the nutrition, growth, and development of infants and toddlers.
Egg products can be prepared in a variety of ways, including as baked-in egg, and lesser cooked forms of egg including pancakes/waffles, French toast, and scrambled/fried egg. Baked egg is egg as a minor ingredient in a baked good that is fully cooked through in dry oven heat, while scrambled/fried egg is an egg that has been cooked on a stove top heat. If a patient reacts to scrambled egg (one of the lesser cooked forms of egg), but is able to tolerate more cooked forms of egg such as pancakes/waffles, it is beneficial to maintain the least cooked form of egg tolerated in that patient’s diet.
Research Behind This Recommendation
- Koplin JJ, et al. JACI 2010; 126:807-13
Can early introduction of egg prevent egg allergy in infants? A population-based study.- 2589 Australian Infants (HealthNuts: population-based cross sectional study)
- Egg introduction at age 4-6 months associated with a lower prevalence of egg allergy versus later introduction
- OR was 1.6 for 10-12 months
- OR was 3.4 for > 12 months
- Perkin, MR, et al. N Engl J Med. 2016;374: 1733-1743
Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants.- 1303 exclusively breast fed 3 months from the general population
- Introduced 6 allergenic foods sequentially including peanut, egg, cow’s milk, sesame, white fish, and wheat
- There was poor compliance with feeding recommendations
- No significant difference in intention to treat group
- Per protocol group had significant reduction in peanut (0 versus 2.5%, p = 0.003) and egg (1.4 vs. 5.5%, p = 0.009) allergy at age 3
- Natsume et al. Lancet 2017; 389:276-286
Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial.- Increasing amounts of heated whole egg powder between 6-12 months of age
- Reduced risk of egg allergy by 78% in infants with eczema
- Palmer DJ, et al. JACI 2017; 139(5):1600-1607
Randomized controlled trial of early regular egg intake to prevent egg allergy.- 820 infants introduced to pasteurized raw egg powder between 4-6 months
- Non significant trend toward a reduced risk of egg allergy compared to introduction at 10 months
- Per protocol analysis found significantly fewer children in the early introduction group had IgE mediated egg allergy at 12 months
- Bellach J et al. JACI 2017; 139(5): 1591-1599
Randomized placebo-controlled trial of hen’s egg consumption for primary prevention in infants.- 383 infants from 4-6 months in the general population
- Trial of pasteurized raw egg white powder or placebo rice powder with primary outcome of egg sensitization at 12 months
- Terminated early due to increased sensitization rate in early egg introduction group at 12 months
- Tan, Valerio et al. JACI 2017; 139(5):1621-1628
A randomized trial of egg introduction from 4 months of age in infants at risk for egg allergy.- 319 infants with family history of atopy, personal skin prick test negative to egg
- Given pasteurized whole egg powder starting at 4 months through 8 months
- At 12 months, significant lower egg sensitization
- Ierodiakonou et al. 2016 Sep 20;316(11):1181-119
Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease: A Systematic Review and Meta-analysis.- Meta analysis of 5 trials
- Egg introduction at 4-6 months was associated with lower risk of egg allergy compared with later egg introduction
- Absolute risk reduction was 24 cases per 1000 (if incidence rate was 5.4%)
- Palmer DJ, et al. JACI. 2013; 132(2):387-392
Early regular egg exposure in infants with eczema: A randomized controlled trial.- 86 infants with moderate to severe eczema (high risk)
- Terminated early due to high rate of allergic reactions in those randomized to early introduction at age 4 months.
Dairy
There is some evidence that early and regular exposure to cow’s milk protein as a supplement to breastfeeding may promote tolerance. Delayed introduction was associated with higher rates of cow’s milk allergy.
Cow’s milk protein can be served to infants in the form of plain, whole milk yogurt, soft, pasteurized cheeses including ricotta, mascarpone, and mozzarella, or whole cow’s milk used as an ingredient in oatmeal or chia seed pudding. Do not serve cow’s milk as a beverage to infants under the age of 12 months.
Research Behind This Recommendation
- Sakihara T, Otsuji K, Arakaki Y, Hamada K, Sugiura S, Ito K. Journal of Allergy and Clinical Immunology. 2021;147(1). doi:10.1016/j.jaci.2020.08.021
Randomized trial of early infant formula introduction to prevent cow’s milk allergy.- Infants were randomized to ingest at least 10 mL of cow milk formula daily or avoid cow milk formula between 1 and 2 months of age. These infants were then assessed for cow milk allergy at age 6 mo.
- The authors of this study concluded that daily ingestion of cow milk formula between 1 and 2 months of age prevents the development of cow milk allergy without interfering with breastfeeding.
- Katz, Y et al. J Allergy Clin Immunol. 2010 Jul;126(1):77-82
Early exposure to cow’s milk protein is protective against IgE-mediated cow’s milk protein allergy. J Allergy- 13,019 infants prospectively followed
- Mean age of cow’s milk protein introduction was significantly lower in non allergic infants than those with cow’s milk allergy
- Onizawa Y et al. J Allergy Clin Immunol Pract. 2016 May-Jun;4(3):481-488.e2
The Association of the Delayed Introduction of Cow’s Milk with IgE-Mediated Cow’s Milk Allergies.- Delaying cow’s milk protein > 1 month after birth or feeding irregularly was associated with higher rate of cow’s milk allergy
- Sicherer, S., Allen, K., Lack, G., Taylor, S., Donovan, S., Oria, M. (2017). Pediatrics, 140(2): e20170194. DOI: 10.1542/peds.2017-0194
Critical issues in food allergy: A national academies consensus report.- Studies have found that early exposure to cow’s milk protein as a supplement to breastfeeding may promote tolerance. Delayed introduction was associated with higher rates of cow’s milk allergy.
Sesame
Early introduction of sesame is safe, and there is some evidence that it may help reduce sensitization.
Sesame should be served in its paste form (i.e., “tahini”) and either drizzled over soft-cooked vegetables, spread into a thin layer on strips of toast, mixed into a familiar puree, or thinned with a little breast milk, formula, or water and served on a spoon.
Research Behind This Recommendation
- Perkin, MR, et al. N Engl J Med. 2016;374: 1733-1743
Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants.- 1303 exclusively breast fed 3 months from the general population
- Introduced 6 allergenic foods sequentially including peanut, egg, cow’s milk, sesame, white fish, and wheat.
- There was poor compliance with feeding recommendations
- No significant difference in intention to treat group
- Per protocol group had significant reduction in peanut (0 versus 2.5%, p = 0.003) and egg (1.4 vs. 5.5%, p = 0.009) allergy at age 3
- Adatia, A., Clarke, A. E., Yanishevsky, Y., & Ben-Shoshan, M. (2017). Journal of Asthma and Allergy, 10, 141–151. doi:10.2147/JAA.S113612
Sesame allergy: current perspectives.- A study examining the effects of early sesame introduction yielded inconclusive evidence, as compliance was low (44%) for the study’s sesame feeding recommendations.
Wheat
There is some evidence that the introduction of wheat cereal before 6 months of life is associated with a reduced risk of wheat allergy.
Wheat can be served in the form of fortified infant wheat cereal, wheat germ mixed into a familiar puree, tender-cooked pieces of pasta, or strips of whole wheat toast topped with mashed avocado or another nutritious spread.
Research Behind This Recommendation
- Abrams E, et al. J Pediatr. 2017 May;184:13-18
Early Solid Food Introduction: Role in Food Allergy Prevention and Implications for Breastfeeding.- Data suggest exposure to cereal grains prior to 6 months is protective for the development of wheat specific IgE
- Poole JA, et al. Pediatrics. 2006 Jun;117(6):2175-82
Timing of initial exposure to cereal grains and the risk of wheat allergy.- Delaying initial exposure to cereal grains until after 6 months may increase the risk of developing wheat allergy
- Nwaru Bi, et al. Pediatrics. 2010 Jan;125(1):50-9
Age at the introduction of solid foods during the first year and allergic sensitization at age 5 years.- 994 Finnish children followed prospectively
- Delayed introduction of multiple foods, including oats and wheat was significantly associated with food allergen sensitization
Tree Nuts and Soy
There are no studies specific to the timing of introducing tree nuts or soy. There is also no data to support delayed introduction.
Tree nuts can be served ground into a powder and mixed into a familiar puree or sprinkled over soft-cooked vegetables. Alternatively, tree nuts can be processed into a nut butter and spread into a thin layer on toast strips, mixed into a familiar puree, or thinned with a little breast milk, formula, or water before serving to an infant.
Soy can be served as silken tofu served on a spoon, in strips of firm tofu, or as mashed or pureed edamame.
- Weinberger et al. J Asthma Allergy. 2018 Mar 26;11:41-51
Current perspectives on tree nut allergy: a review.- There is currently limited evidence
- Do not give loose nuts until 5 year old (choking hazard)