Food Allergy Management and Prevention
Support Tool for Infants and Toddlers
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For Early Food Introduction

Allergenic Food History:

This section can be used to document the patient’s history of exposure or reaction to the most common allergens. You can copy and paste it into your EMR system to use during well-child visits or follow up appointments.

Egg: [SELECT ONE: in diet and tolerated, never, tried, reaction from eating, reaction from touching, positive skin prick test, positive blood test, previously tolerated but no longer eaten]

Peanut: [SELECT ONE: in diet and tolerated, never tried, reaction from eating, reaction from touching, positive skin prick test, positive blood test, previously tolerated but no longer eaten]

Tree nut (e.g. almond, walnut, cashew, pecan, pistachio, hazelnut, brazil nut): [SELECT ONE: in diet and tolerated, never tried, reaction from eating, reaction from touching, positive skin prick test, positive blood test, previously tolerated but no longer eaten]

Dairy: [SELECT ONE: in diet and tolerated, never tried, reaction from eating, reaction from touching, positive skin prick test, positive blood test, previously tolerated but no longer eaten]

Wheat: [SELECT ONE: in diet and tolerated, never tried, reaction from eating, reaction from touching, positive skin prick test, positive blood test, previously tolerated but no longer eaten]

Soy: [SELECT ONE: in diet and tolerated, never tried, reaction from eating, reaction from touching, positive skin prick test, positive blood test, previously tolerated but no longer eaten]

Sesame: [SELECT ONE: in diet and tolerated, never tried, reaction from eating, reaction from touching, positive skin prick test, positive blood test, previously tolerated but no longer eaten]

Fish: (e.g. cod, tuna, salmon, haddock, tilapia, etc): [SELECT ONE: in diet and tolerated, never tried, reaction from eating, reaction from touching, positive skin prick test, positive blood test, previously tolerated but no longer eaten]

Shellfish: (e.g. shrimp, clam, lobster, crab, scallop, mussels): [SELECT ONE: in diet and tolerated, never tried, reaction from eating, reaction from touching, positive skin prick test, positive blood test, previously tolerated but no longer eaten]

Allergenic Introduction Assessment and Plan:

This text includes information on how to manage peanut introduction for infants at high risk of developing a peanut allergy, as well as how to guide parents on early food introduction for foods other than peanut. You can copy and paste it into your EMR system to use during well-child visits or follow up appointments.

[PLEASE LEAVE IN IF PATIENT HAS NOT EATEN PEANUT]
Food Introduction (Peanut)
Per the addendum NIAID/LEAP guidelines, babies at high risk for peanut allergy should be introduced to peanut between 4-6 months of age in an age appropriate way (i.e. no loose nuts until age 5 and use of thinned out peanut butter). The Guidelines define high risk as patients with severe eczema, egg allergy, or both. Per the NIAID guidelines, if the eczema is severe then a peanut specific IgE and/or peanut skin testing should be done before introduction. [FOR PROVIDER: PLEASE CONSIDERING SPEAKING TO COMMUNITY ALLERGIST TO DISCUSS IF BLOOD TEST SHOULD BE SENT BY PROVIDER OR THE PATIENT SHOULD BE REFERRED TO AN ALLERGIST FOR SKIN TESTING].

Pathway:
Referral to Allergist
The patient is considered high risk for peanut allergy due to their severe eczema or IgE mediated food allergy to another food. The patient will be referred to an allergist for peanut skin testing evaluation. Until the testing has been done the patient should avoid any consumption of peanuts. After the peanut skin test the allergist will decide if it is safe for the patient to eat peanut. The patient was given a hand out on how to read a label and cross contact patient education. [NOTE TO DOCTOR TO PROVIDE LABEL READING AND CROSS CONTACT PATIENT EDUCATION].

Blood test
The patient is considered high risk for peanut allergy due to their severe eczema or IgE mediated food allergy to another food. Peanut IgE with reflex components was ordered. If the testing is negative (<0.35), please introduce peanut into the child’s diet using the introduction resource as guidance. If the testing is positive, an appropriate epinephrine auto-injector two pack will be prescribed and a referral for Pediatric Allergy/Immunology evaluation will be placed as well as an allergy anaphylaxis plan. Instructions on allergen avoidance and label reading will be provided. [NOTE TO DOCTOR TO PROVIDE LABEL READING, ALLERGY ANAPHYLAXIS PLAN AND CROSS CONTACT PATIENT EDUCATION]. If the patient is able to introduce peanut at home the office will provide a hand out on peanut introduction at home.

Food Introduction (Allergenic Foods OTHER THAN Peanut)
The 2019 AAP Clinical Report recommends dietary interventions to prevent atopic disease, and states that there is no evidence that delaying introduction of other allergenic foods beyond 4-6 months prevents atopic disease. The dual exposure hypothesis theorizes that tolerance to a food is developed by exposure through the GI tract, whereas sensitization to a food is developed by cutaneous exposure. There is also data to show that the sensitization is increased by eczema and compromises in the skin barrier. Therefore the family was counseled that repeated cutaneous exposure to highly allergenic foods not yet eaten can lead to sensitization and if there are any concerns please call the office. Discussed that in order to limit the child’s cutaneous exposure to allergenic foods not eaten it is best to avoid them in the child’s play area; restrict eating to a table that is thoroughly cleaned after ingestion as well as dishware and wash hands after handling foods and before touching the child or applying creams or lotions.

We recommend food introduction in an age-appropriate (and culturally appropriate) manner free of choking hazards (i.e. do not give whole peanuts, tree nuts, and/or seeds; recommend thinned nut butter mixed in cereal/formula/breastmilk/pureed fruit or vegetables). We recommend gradual introduction, starting with a pea sized amount and doubling this every 10 to 20 minutes until they have reached about 2 tablespoons, but this can be done more slowly in a higher risk patient. When introducing foods at home the family was counseled to be aware of the signs of anaphylaxis. Symptoms of anaphylaxis can include hives, swelling, wheezing, cough, shortness of breath, nausea, vomiting, difficulty breathing, dizziness, or loss of consciousness. If foods are introduced and tolerated it is important to keep them in the diet at a regular interval.

If there is any concern please call our office at [INSERT PHONE NUMBER] or call 911.

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For Early Food Introduction

These sections contain the same information as in the PDF handouts throughout this section but are formatted for easier placement within EMR systems to place in after visit patient handouts.

Helpful Tips and Tricks for Allergy Prevention

Helpful Tips and Tricks for Allergy Prevention

The dual exposure hypothesis is a belief that the ability to eat a food without a reaction (tolerance) is developed by having the GI tract see the food, whereas the potential for food allergy is developed by skin exposure to the food, which can be worsened by eczema or skin breakdown. It is important to try to prevent repeated skin exposure to foods that your child has not eaten yet. To try to limit skin exposure it is best to avoid eating allergenic foods in your child’s play area and restrict eating to the table.  It is important to clean surfaces where food is prepared or eaten to help reduce your child’s environmental exposure to any food allergens. Limit snacking throughout the house to reduce the amount of food dust/particles that get on rugs, carpets, etc. It is best to wash your hands before applying lotions and creams and after handling foods.

 

Peanut Introduction as per NIAID/LEAP

Why should I introduce peanut products to my baby so early in life?

Introducing peanut products to your baby early in life can help prevent him from developing a peanut allergy later on. Ask your doctor when it is right to introduce peanut products for the first time.

What should I do before giving my baby peanut products for the first time?

Talk with your baby’s doctor about whether he is ready to try peanut products.

If your baby has other known food allergies or very bad eczema (dry, scaly patches of skin), ask your doctor if your baby should have an allergy test or see a pediatric allergist (allergy doctor).

How do I introduce peanut products?

Safety tips

Give the first taste when your baby is healthy. Do not give the first taste if he has a cold, fever, diarrhea or other illness.

Give your baby his first taste of peanut products at home. Do not give the first taste at daycare or in a restaurant.

Timing tips

Set aside at least 2 hours after the first taste to watch your baby for a reaction. Make sure you or another family member can give full attention to your baby.

For the very first taste, give a small amount, the tip of a small spoon. Wait 10 minutes between the first and second taste. If your baby does not have any reaction after 10 minutes, give the rest of the peanut butter at his normal eating speed.

Give your baby 2 teaspoons (6 grams) of peanut products at least 3 times per week. This will help prevent him from developing a peanut allergy later in life.

Tips while your child eats:

Prepare a full serving of peanut butter from the recipe below.

Offer the first taste on a small spoon.

For babies and children under age 4, mix peanut butter with 1 safe food at a time. Do not give plain peanut butter to any baby or child under age 4.

Do not push your baby to eat more than he wants.

Peanut recipes for babies

Option 1: Peanut butter puree

You will need:

2 tsp. smooth, all-natural peanut butter (with no added ingredients)

2-3 tbsp. of plain yogurt or pureed (smooth) fruit or vegetable that your baby likes

Mix peanut butter and yogurt or fruit or vegetable puree. Add more water if you want the puree to be thinner.

Option 2: Peanut butter powder sauce

You will need:

2 tsp. powdered peanut butter or peanut flour

2-3 tbsp. of warm water, oatmeal, applesauce or mashed banana

Mix peanut butter or peanut flour with the water, oatmeal, applesauce or banana.

Let the mixture cool.

Add more water if you want the mixture to be thinner.

Option 3: Bamba® peanut butter puffs

You will need:

21 Bamba® peanut butter puffs

For babies aged 7 months and under, soften puffs in 4-6 tbsp. of water. Feed your baby one puff at a time.

For babies older than 7 months or who can eat dissolvable solids, feed puffs one at a time as normal.

A note about choking

Only give your baby smooth peanut butter.

Never give your baby chunky or crunchy peanut butter. Your baby can choke on the small peanut pieces.

Never give your baby whole peanuts or pieces of peanuts.

A note about food allergies

When your baby is trying a peanut product for the first time, it is important to watch him for signs of a food allergy. An allergic reaction can happen up to two (2) hours after trying a new food.

What is a food allergy?

A food allergy is when your body mistakes a certain food for something dangerous or unknown.

What are common signs of a food allergy?

Rash or hives (swollen red bumps) around the mouth or on the face or body

Swollen lips, tongue or face

Itching

Vomiting

Coughing

Change in skin color (blue or pale)

Wheezing (whistling sound when you breathe in)

Trouble breathing

Suddenly feeling tired or drowsy

Feeling like your body is going limp

What to do if your baby has an allergic reaction

Call 911 or take your baby to the emergency room right away.

If your baby’s allergist (allergy doctor) has created a Food Allergy Action Plan, follow the steps.

Helpful Tips and Tricks for Allergy Prevention

The dual exposure hypothesis is a belief that the ability to eat a food without a reaction (tolerance) is developed by having the GI tract see the food, whereas the potential for food allergy is developed by skin exposure to the food, which can be worsened by eczema or skin breakdown. It is important to try to prevent repeated skin exposure to foods that your child has not eaten yet. To try to limit skin exposure it is best to avoid eating allergenic foods in your child’s play area and restrict eating to the table.  It is important to clean surfaces where food is prepared or eaten to help reduce your child’s environmental exposure to any food allergens. Limit snacking throughout the house to reduce the amount of food dust/particles that get on rugs, carpets, etc. It is best to wash your hands before applying lotions and creams and after handling foods.

Food Introduction (other than peanut)

It is best to introduce new foods to your child in an age-appropriate and culturally appropriate manner. The foods should be free of choking hazards, such as whole nuts and thinned by mixing them with formula, breast milk, or pureed fruits or vegetables. There is no reason to delay the introduction of foods that are considered “allergenic” like, tree nuts, eggs, dairy, soy, wheat, sesame, fish, and shellfish beyond 4-6 months of exclusive breat feeding.  We recommend that you start with a tip of a teaspoon and double this every 10 to 20 minutes until your child has reached about 2 grams of the allergen protein. The amount of protein can be found on the nutrition label. For example, about 2 teaspoons for nut-butters, and sesame tahini) and about 1/3rd of a large egg have 2 grams of those specific proteins.  

This initial food introduction can also be done more slowly if you or your provider have any concerns. It is important to be aware of the signs of an allergic reaction or anaphylaxis.  These symptoms include hives, swelling, wheezing, cough, shortness of breath, nausea, vomiting, difficulty breathing, or loss of consciousness. If you have any concerns it is important to call 911. Please let your provider know if there are any signs of a reaction because a referral to an allergist will be made. If foods are tolerated it is important to keep them in the diet in regular intervals.

Videos for Parents for Peanut Introduction as per Addendum Guidelines

What Parents Should Know [English]: https://players.brightcove.net/6056665225001/5cmMqFpv5_default/index.html?videoId=6216466727001

What Parents Should Know [Spanish]:
https://players.brightcove.net/6056665225001/5cmMqFpv5_default/index.html?videoId=6216471682001

Introducing Complimentary Foods

When is an infant ready for solid food, and what foods are developmentally appropriate?

If serving purees, aim for a smooth, even texture for your baby’s first few foods. First finger foods given to an infant should be very soft and easy to smash between your thumb and forefinger. For thicker foods, such as nut butters, it is best to thin them out with warm water or mix them into something smoother, such as applesauce. Some signs that a baby is ready to try solid foods are:

  • Good head and neck control
  • Ability to sit on their own with minimal support
  • Opens mouth and leans forward when offered food
  • Able to grasp larger objects and bring them up to the mouth

Some infants may show developmental signs of readiness before age 6 months but introducing complementary foods before age 4 months – or waiting until after 6 months – is not recommended.

Nutrition Guidance for Children During their First 12 Months of Life

The American Academy of Pediatrics states that: “There is no evidence that delaying the introduction of allergenic foods, including peanuts, eggs, and fish, beyond 4 to 6 months prevents atopic disease.”

Why is infant nutrition so important?

During an infant’s first year of life, infants should receive adequate amounts of essential nutrients because these foods are needed for healthy brain development and overall growth. Also, establishing healthy dietary patterns early in life can influence eating behaviors and overall health throughout the course of life.

Key Recommendation

Between ages 0-4 months: Exclusive breastmilk and/or formula feeding

  • What form of milk? Human breast milk, iron-fortified infant formula, or a combination of both
  • Do I need to supplement the milk with anything?
    •  You may need to provide a vitamin D supplement, depending on which form of milk you choose
      •  For exclusive human breastmilk feeding, vitamin D supplement of 400 IU per day
      • For breast milk/formula mixed feeding, vitamin D supplement of 400 IU per day
      • For exclusive iron-fortified formula feeding, no vitamin D supplement is needed since infant formula is vitamin-fortified

Between 4-6 months: When your child is ready, start to introduce complementary foods

  • How do I know when my child is ready?
    • The ages infants show signs of readiness vary and are typically between ages 4 and 6 months.
    • Signs that your child may be ready for complementary foods include:
      • Being able to control the head and neck
      • Sitting up alone or with support
      • Bringing objects to the mouth
      • Trying to grasp small objects, such as food or toys
      • Swallowing food rather than pushing it back out onto the chin
      • Swallowing food rather than pushing it back out onto the chin
    • There is no evidence that delaying the introduction of allergenic foods helps prevent food allergy (Please see information specific to high-risk infants below)

Between 6-12 months: Introduce complementary foods no later than 6 months

  • What complementary foods should I give my child?
    • Infants should be encouraged to consume a variety of complementary foods
      • Introduce iron-rich foods: meats seafoods, iron-fortified infant cereals
      • Introduce zinc-rich foods: meats, beans, zinc-fortified infant cereals
      • Introduce a variety of foods from all food groups: protein, fruits and vegetables, dairy, grains
      • Introduce potentially allergenic food groups: egg, dairy, peanuts, tree nuts, soy, shellfish, fish, wheat, sesame.

How do I know if my child is at high risk of developing a peanut allergy?

  • Risk factors: If your child has severe eczema, egg allergy, or both, s/he may be at a higher risk of developing a peanut allergy

Recommendations: age-appropriate, peanut-containing foods should be introduced to the diet as early as age 4 to 6 months.

Establishing Healthy Dietary Patterns in an Infant’s First Year of Life

Dietary Components to encourage:

  • A wide variety of fruits, especially berries and whole fruits
  • A wide variety of vegetables from each vegetable group, which includes dark green (ex. broccoli), red/orange (ex. carrots), legumes (i.e., beans, peas, lentils), starchy vegetables (ex. potatoes)
  • Whole grains
  • Unprocessed meat

Dietary Components to limit:

  • Processed meats (ex. cold cuts)
  • Refined grains
  • 100% fruit juice
  • Foods with high sodium content
  • Foods containing added sugars

Dietary Components to Avoid:

  • Honey and unpasteurized foods and beverages
  • Sugar-sweetened beverages (ex. soda, sweet tea)
  • Liquid cow’s milk, fortified soy beverages, and milk alternatives (such as plant-based milk) in place of breast milk or infant formula
  • Caffeinated beverages
  • Seafood with high mercury content
  • Loose nuts and other choke-risk foods

Introducing your child to the 9 major allergens:

The 9 major potentially allergenic foods should be introduced as complementary foods. There is evidence that introducing peanut-containing foods in an infant’s first year of life can reduce the risk that s/he will develop a peanut allergy There is no evidence that delaying introduction of allergenic foods beyond 6 months prevents food allergy.

  1. Dairy
  2. Egg
  3. Peanuts
  4. Tree Nuts
  5. Soy
  6. Wheat
  7. Fish
  8. Shellfish
  9. Sesame

Dot phrases modified from PDF found at: https://famp-it.org/wp-content/uploads/aap-statement-FAMPIT_Nutrition-Education_less12mo.pdf

Nutrition Guidance for Children After Their First Birthday

Nutrition Education Adapted from the 2020-25 Dietary Guidelines’ New Chapter on Infant and Toddler Nutrition

Following healthy dietary patterns early on is important for maintaining proper growth, and nutritional needs, and reducing the risk for chronic disease later in life. You can help your child establish healthy eating habits by encouraging them to eat a variety of nutrient-dense foods from all the food groups. You can start by replacing less healthy snacks and ingredients with nutrient-dense alternatives!

Dietary Components to LIMIT:

  • Processed meats (e.g., cold cuts)
  • Foods with high sodium content
  • Food containing added sugars
  • 100% fruit juice, even if it doesn’t have added sugar

Dietary Components to AVOID:

  • Sugar-sweetened beverages (e.g., soda, juice drinks, sports drinks)
  • Caffeinated beverages
  • Alcoholic beverages
  • Seafood with high mercury content
  • Loose nuts and other choke-risk foods

It is important to choose nutrient-dense foods from each food group!

  • Fruit
    • All fresh, frozen, canned in 100% fruit juice, and dried fruits
    • Examples: apples, pears, oranges, grapefruit, berries (i.e., blueberries, raspberries, strawberries), bananas, melons, peaches, plums, raisins, papaya, pomegranate
    • Encourage whole fruits, limit fruit juice to 4 ounces per day
  • Veggies
    • Dark Green Vegetables: broccoli, bok choy, collards, kale, mustard greens, spinach
    • Red & Orange Vegetables: carrots, pumpkin, squash, bell peppers, sweet potatoes, tomatoes
    • Beans, Peas, Lentils: black beans, garbanzo beans, edamame, kidney beans, lentils, split peas, pinto beans
    • Starchy Vegetables: plantains, white potatoes, corn, yam, yucca, water chestnuts
    • Other Vegetables: asparagus, beets, Brussels sprouts, cauliflower, green beans, eggplant, cucumber, turnips, seaweed
  • Dairy
    • All fluid, dry, or evaporated milk (includes lactose-free/reduced products and fortified soy beverages)
    • Examples: milk, buttermilk, yogurt, kefir, cheese
    • Limit cream, sour cream, frozen yogurt, ice cream, and cream cheese
  • Grains
    • Whole grains: brown rice, oats, quinoa, whole-grain cereals/crackers, dark rye, barley (not pearled), whole-grain cornmeal, whole-wheat bread
    • Refined grains: white rice, white breads, refined-grain cereals/crackers, pasta, cream of wheat/rice, corn grits
    • Encourage whole grains, limit refined grains
  • Protein 
    • Meats, Poultry, Eggs: beef, goat, lamb, pork, chicken, duck, goose, turkey, organ meats, chicken eggs and other birds’ eggs
    • Seafood: anchovy, black sea bass, clams, cod, crab, flounder, haddock, lobster, oyster, salmon, sardine, scallop, shrimp, sole, squid, light tuna
      *avoid seafood high in mercury
    • Nuts, Seeds, Soy: tree nuts, peanuts, nut butters, seeds, seed butters, tofu, tempeh, soy protein isolate, soy concentrate

Dot phrases modified from PDF found at: https://famp-it.org/wp-content/uploads/FAMPIT_Nutrition-Education_more12mo.pdf

EMR
Documentation

Patient
Instructions

Prevention of Peanut Allergy

NIAID Guidelines and Background

baby eating peanut butter

Recent studies, including the Learning Early About Peanut (LEAP) study, demonstrate that early introduction of peanuts in children considered at high risk of developing peanut allergy can decrease peanut allergy. Based on the LEAP study, the NIAID Addendum Guidelines were released in 2017 and outline strategies for the early introduction of peanuts into the diets of all children in the United States [3]. They currently recommend the introduction of developmentally appropriate forms of peanut (with a goal of about 2grams of peanut protein, 3x a week) and outline timing, developmentally appropriate forms of peanut, how to assess risk, etc [3].

The American Academy of Pediatrics (AAP), the US Department of Agriculture (USDA), and the US Department of Health and Human Services (HHS) have released guidance documents that support the above recommendations. The NIAID guidelines suggest screening in high-risk children, those with severe eczema and/or an egg allergy, and no screening is necessary for children with no risk factors.  Screening is also unnecessary for positive family history of allergy, and mild and moderate eczema.

The AAP released a 2019 Clinical Report that endorsed the NIAID Addendum Guidelines. This report includes the mention of potential issues with the screening recommendation. In this report, they stated that “It is hoped that the screening process for the infants at highest risk (specific IgE measurement, skin-prick test, and oral food-challenge test) will not be a deterrent or generate “screening creep” for infants not in the high-risk category.” These guidelines may be difficult to follow in communities without access to the medical care needed for implementation. Also relevant is the statement, “The guidance in this report does not indicate an exclusive course of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be appropriate” (6).

Main Takeaways

  • Early introduction of peanuts in high-risk children, as recommended by the NIAID Addendum Guidelines, has been shown to decrease the risk of developing peanut allergy.
  • The AAP, USDA, and HHS endorse the NIAID recommendations, providing clear screening criteria for high-risk children (severe eczema and/or egg allergy). Children with no risk factors; children with mild or moderate eczema; and children with a positive family history of allergy do not require screening.
  • The AAP’s 2019 Clinical Report supported the NIAID Addendum Guidelines, but noted potential screening challenges. They hoped that high-risk infant screening wouldn’t affect low-risk infants. Implementing the guidelines in communities with limited medical access could be difficult. The report emphasized flexibility in treatment, tailored to individual circumstances, rather than a strict standard of care.

NIAID Addendum Guideline Summary


Infant CriteriaRecommendationsEarliest Age of Peanut Introduction
Severe eczema, egg allergy, or bothStrongly consider evaluation with peanut-specific IgE and/or skin prick test and, if necessary, an oral food challenge. Based on test results, introduce peanut-containing foods.4 to 6 months
Mild to moderate eczemaIntroduce peanut-containing foods.Around 6 months
No eczema or any food allergyIntroduce peanut-containing foods.Age appropriate and in accordance with family preferences and cultural practices

High Risk Infants

Infants considered high-risk for peanut allergy are those with severe eczema, egg allergy, and/or any other known IgE-mediated food allergy. The NIAID defines severe eczema as “Persistent or frequently recurring eczema with typical morphology and distribution assessed as severe by a healthcare provider and requiring frequent need for prescription-strength topical corticosteroids, calcineurin inhibitors, or other anti-inflammatory agents despite appropriate use of emollients (3).” Hospital systems may have varied approaches to implementing the NIAID guidelines.

According to the guidelines, referring them to a pediatric allergist for evaluation and possible skin testing is recommended. You can also send a blood test for peanut-specific IgE, and if that is positive, order a referral for a pediatric allergist.

If the peanut-specific IgE is negative, you can advise the family to introduce peanuts at home when the infant is 4-6 months of age or ready to try solid food. You can provide them with a copy of the handout entitled “Introducing Peanut Products to Your Baby.”  

Feel free to view the sample approach by Lurie Children’s Hospital on implementing the NIAID guidelines within their system.

Courtesy of the Food Allergy Center for Food Allergy & Asthma Research

Moderate Risk Infants

These infants are those with mild to moderate eczema or another food allergy. For these infants, you can recommend the families introduce peanuts at home, starting at 6 months of age, and follow the family’s preferences and cultural practices. Consider referring the family to an allergist to manage the known food allergy, but do not delay peanut introduction. Provide them with a copy of the handout entitled “Introducing Peanut Products to Your Baby”.

Courtesy of the Food Allergy Center for Food Allergy & Asthma Research

Low Risk Infants

low risk baby

Infants who have no eczema or food allergy are considered low risk. For these infants, recommend families to introduce peanuts at home according to their individual preferences and cultural practices. Provide them with a copy of the handout entitled “Introducing Peanut Products to Your Baby”.

Courtesy of the Food Allergy Center for Food Allergy & Asthma Research

Main Takeaways

  • Severe eczema, egg allergy, or both:
    • Goal is to introduce peanut-containing foods at 4 to 6 months.
    • Consider screening (allergy referral or sending peanut-specific IgE).
    • If screening causes delays, consider a supervised feeding.
  • Mild to moderate eczema:
    • Introduce peanut-containing foods at around 6 months.
    • There is no need for screening.
  • No eczema or any food allergy:
    • Introduce peanut-containing foods at an age-appropriate time, per family preferences and cultural practices.
    • There is no need for screening.

Alternatives to NIAID Approach

The American Academy of Allergy, Asthma, and Immunology, the American College of Asthma, Allergy, and Immunology, and the Canadian Society of Allergy and Clinical Immunology support the recent publication- A Consensus Approach to the Primary Prevention of Food Allergy Through Nutrition that de-emphasizes the need for screening that is suggested in the NIAID Addendum Guidelines.

DOWNLOAD
A Consensus Approach to the Primary Prevention
of Food Allergy Through Nutrition

This consensus document recommends that all infants, irrespective of relative risk, introduce peanut-containing foods and egg at 4-6 months when the infant is developmentally ready for complementary foods. Also highlighted is the importance of shared decision-making as families consider the introduction (4).

Currently, the United States is the only country with a screening step. In countries including Australia, Israel, and the United Kingdom without similar screening steps that recommend peanut introduction, reactions are rare. Specifically, the British Society of Allergy and Clinical Immunology (BSACI) guidelines state– “The benefits of allergy testing in higher-risk babies before introducing egg or peanut needs to be balanced against the risk this could cause a delay (due to lack of available testing) and increase the risk of food allergy”(5). Even in infants who already have food allergies, including those with severe eczema, “The risk of a severe reaction (anaphylaxis) is low (1-2 per 1000) in these babies” (5).

Since the 2017 release of the NIAID guidelines and the 2019 release of the American Academy of Pediatrics Clinical Report, Keet and colleagues have published on the use of Arah2, and have reported that it is a more sensitive and specific screening tool for clinically relevant peanut allergy as compared to peanut-specific IgE or peanut skin prick test in high-risk infants (6).

Main Takeaways

  • The American Academy of Allergy, Asthma, and Immunology, the American College of Asthma, Allergy, and Immunology, and the Canadian Society of Allergy and Clinical Immunology support a recent consensus approach to food allergy prevention through nutrition.
  • The consensus recommends introducing peanut-containing foods and egg at 4-6 months, regardless of relative risk and when the infant is developmentally ready.
  • Unlike the United States, other countries like Australia, Israel, and the UK, which do not have similar screening steps, have rare reactions to early peanut introduction.
  • Even in infants with existing food allergies or severe eczema, the risk of severe reactions is low.

Timing Matters

Whether you adhere to the NIAID Addendum Guidelines or the Consensus Approach, it is important to target peanut introduction between 4 to 6 months of age.

In the recent publication Age and eczema severity, but not family history, are major risk factors for peanut allergy in infancy, Keet and colleagues demonstrated that in kids with severe eczema, the chance of peanut allergy significantly increases with time. While less than 20% of children under 6 months had a positive oral food challenge to peanuts, about 50% of children over 8 months had a positive oral food challenge to peanuts (7). These findings reinforce the importance of not delaying the introduction of peanuts.

You can start talking about peanut introduction with families even in the newborn period and help families anticipate the introduction of peanut-containing foods, as well as other allergens, as early as 4-6 months of life, especially in high-risk infants.

Main Takeaways

  • Regardless of the chosen guideline (NIAID or Consensus Approach), introducing peanuts between 4 to 6 months is crucial.
  • Severe eczema and age are significant risk factors for peanut allergy in infants; delaying introduction increases the risk.
  • Begin discussions about peanut introduction with families early, even in the newborn period, and help them prepare for introducing peanuts and other allergens at 4-6 months, especially for high-risk infants.

Resources for Parents for the Early Introduction of Peanut:

peanut allergy prevention through early introduction
AAP’s Online Course: Peanut Allergy Prevention through Early Introduction
Introducing Peanut Products to Your Baby

Download in
English or Spanish

Parent Magazine article about early peanut introduction
Parent Magazine article about early peanut introduction

Videos for Parents for Peanut Introduction as per Addendum Guidelines

Test your knowledge


References

  1. Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, Brough HA, Phippard D, Basting M, Feeney M, Turcanu V. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015 Feb 26;372:803-13.
  2. Perkin MR, Logan K, Tseng A, Raji B, Ayis S, Peacock J, Brough H, Marrs T, Radulovic S, Craven J, Flohr C. Randomized trial of introduction of allergenic foods in breast-fed infants. N Engl J Med. 2016 May 5;374:1733-43.
  3. National Institute for Allergy and Infectious Disease. Addendum Guidelines for the Prevention of Peanut Allergy in the United States.; 2017. doi:10.1097/01.JAA.0000512231.15808.66
  4. Fleischer DM;Chan ES;Venter C;Spergel JM; Abrams EM;Stukus D;Groetch M;Shaker M;Greenhawt M; “A Consensus Approach to the Primary Prevention of Food Allergy Through Nutrition: Guidance from the American Academy of Allergy, Asthma, and Immunology; American College of Allergy, Asthma, and Immunology; and the Canadian Society for Allergy and Clinical Immunology.” The Journal of Allergy and Clinical Immunology. In Practice, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/33250376/. 
  5. Preventing food allergy in your baby. BSACI. https://www.bsaci.org/wp-content/uploads/2020/02/pdf_Infant-feeding-and-allergy-prevention-PARENTS-FINAL-booklet.pdf. Published February 20, 2020. Accessed October 11, 2022. 
  6. Keet C, Plesa M, Szelag D, et al. Ara h 2-specific IgE is superior to whole peanut extract-based serology or skin prick test for diagnosis of peanut allergy in infancy. J Allergy Clin Immunol. 2021;147(3):977-983.e2. doi:10.1016/j.jaci.2020.11.034
  7. Keet C, Pistiner M, Plesa M, Szelag D, Shreffler W, Wood R, Dunlop J, Peng R, Dantzer J, Togias A. Age and eczema severity, but not family history, are major risk factors for peanut allergy in infancy. Journal of Allergy and Clinical Immunology. 2021.
  8. U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2020-2025. 9th Edition. December 2020. Available at DietaryGuidelines.gov.